Drug Delivery through blood-brain Barrier
Drugdelivery to the brain is the process of passing therapeutically active molecules across the blood–brain barrier for the purpose of treating brain maladies. Drug Transport into Brain via Blood–Brain Barrier Carrier-Mediated Transporters.Gabapentin is a water-soluble drug that is active in the CNS because the drug crosses the BBB on the large neutral amino-acid transporter,72 which is LAT1.Substances cross the blood-brain barrier (BBB) by a variety of mechanisms. These include transmembrane diffusion, saturable transporters, adsorptive endocytosis, and the extracellular pathways. he blood-brain barrier is an important conduit of nutrients and cells from theblood to the brain. It also has an important function in protecting the brain from the entry of harmful substances.
- Track 1-1 Development and Maturation of CNS Barriers
- Track 2-2 Model Systems to Study CNS Barriers
- Track 3-3 Imaging and Function of the BBB in Health and Disease
- Track 4-4 Therapy and Bioherapeutic Transport Across the BBB
- Track 5-5 The Gut Brain Axis and Neuroimmune Interactions