World Drug Delivery and Formulation Summit

Transdermal therapeutic systems are defined as self-contained, self-discrete dosage forms applied to the intact skin deliver the drug at a controlled rate to the systemic circulation. Transdermal patches include a method of delivering medication through the skin in a noninvasive manner. The patch contains the medication prescribed to the patient and they are simple to use. The classification of TDDS are: Polymer membrane permeation controlled, Polymer matrix diffusion controlled, Drug reservoir gradient controlled, Micro reservoir dissolution controlled. The equipment used for transdermal patches are For-fill seal, lamination, die-cutting, pouching whereas the manufacturing steps are blending, coating process, lamination of backing, rolling of the laminate, punching, pouching and cartooning.

Targeted Drug Delivery system refers that the medicament is selectively targeted or delivered only to its site of action or absorption and not to the non-target organs or tissue or cells. Whereas it is a method of delivering medication to a patient in a manner that increases the concentration of the medication in some parts of the body relative to others. It is used to treat most frightful diseases like cardiac, cancers, Diabetes. It consists of a drug and carrier in passive targeting whereas in active targeting it consists of a drug, a carrier and a ligand. There are 3 basic approaches of targeting which are passive, inverse, active.

Now a days rapidly increasing variety of skin care products that are available in the market and it seems to be difficult to select one which features the best and the most effective formulation. There are different types of formulations for cosmetics which are mainly oil in water cosmetic formulation, water free cosmetic formulation, water in oil, oil free cosmetics, multiple emulsions, liposomes. Whereas these formulations are applicable for skin care products, body care solutions, hair care, face care products. 

Drug delivery systems are engineered technologies used for the targeted delivery and controlled and prolonged release of therapeutic agents. Subsequently the search for new drug delivery approaches and new modes of action is a rapidly developing field. Drug delivery systems can be advanced to target common and rare diseases. Designing of new drug delivery system has the potential to enhance the use of existing use of medicines whereas finding suitable carrier for a drug is significant to confirm it is released at the correct location within the body. The use of drug delivery may allow the drugs which were previously regarded as unsafe. The evident quick development of scientific work and strong in both experimental and clinical aspects of developments in new Drug delivery system.

Nanotechnology has become a vital element of pharmaceutical sciences and finds multiple applications in drug delivery in enhancing therapeutic performance of drugs. Nanotechnology in drug delivery is beneficial to classify drug delivery based on time period representing before and after the nanotechnology revolution. Drug delivery approaches that control and target delivery are important to achieve clinical efficacy whereas approaches involve gold nanoparticles for targeting tumor sites and elastic capsules using Nano sized flakes. Nanotechnology is already producing new dosage forms for injectable drugs that are easier to administer for the patient. Moreover, it is also producing new opportunities in Implantable delivery systems. 

Generic product is well-defined as a drug product that is comparable to branded innovator product in dosage form, strength, route of administration, quality and performance characteristics and intended use. Preformulations are classified into fundamental, derived and compatibility studies. For generic product compatibility studies are most important preformulation study. Many pre-formulation studies should be performed nevertheless generic product can be considered a duplicate of the innovator product. There is a difference in the material properties of the API and excipients used by innovator and generic manufacturer can knowingly affect performance of the dosage form. Therefore, it is important to perform preformulation studies for generic products.

Herbal formulation defines as a mean dosage form consisting of one or more herbs in specified quantities to provide specific nutritional, cosmetic benefits and used to treat, diagnose, mitigate diseases of human beings. Herbal drugs/herbal formulations are finished labelled products that contain active ingredients such as aerial or underground parts of plant or combinations whether in the crude state or as plant preparations. Herbal preparations are available in different forms including fresh, dried, in tablets, or capsules, or bottled in liquid form. Very rare pharmaceutical companies are involved in drug discovery screening from natural sources.

A particle with at least one dimension less than 100nm is a nanoparticle. They are composed of synthetic or semisynthetic polymers carrying drugs or proteinaceous substances. Nanoparticles have developed as capable vehicles to deliver drugs in the body. Nanoparticles comprising encapsulated, dispersed, absorbed or conjugated drugs have exceptional characteristics that can lead to higher performance in a variety of dosage forms. Nanoparticles are one of the novel drug delivery systems which can be of potential use in controlling and targeting drug delivery as well as in cosmetic textiles and paints. There are recent developments in the use of nanoparticles as drug delivery systems to treat a wide variety of diseases.

Pharmaceutical products are formulated to specific dosage forms for drugs to be effectively delivered to patients. It is important to use an effective methodology whereas design of experiments and statistical analysis have been applied to formulation development and used for optimization and process validation. Formulation is the composition of a drug product that contains APIs and other inactive ingredients. In formulation the different types of are designing such as liquid, suspension, powder, solid solution, semisolid formulations. Number of technologies precisely designed to address the common problems in drug formulations. 

Drug design mentioned as rational drug design is the creative process of finding new medications based on the knowledge of a biological target. New techniques are continually being developed to enhance productivity of the drug design process. In a survey of currently available market drugs 21000 registered in USA drugs and only1357 were unique. Whereas, 1204 were small molecule drugs and 166 were biological agents. In structure based drug design, it based on the knowledge of drugs three-dimensional structure and how its shape and charge cause it to interact with its biological target, ultimately elucidating a medical effect. 

Biopharmaceutical products are molecules that are the components of biological systems that are used in the treatment of human and animal health and disease. Formulation development of biopharmaceutical protein therapeutics. Production of biopharmaceutical involves many different, complex and lengthy steps which are synthesis, purification, formulation, final dosage preparation. Applications of biopharmaceuticals are agonist and antagonist of important receptors and enzymes, vaccines. The combination of biological molecules like antibodies with cytoxic compounds and agents, such as antibody drug used in cancer therapies.

Polymers play an important role in the DDS by providing controlled release of therapeutic agents in constant doses over long periods. Polymers have different kind of applications using in various dosage forms such as binders, suspending agents, emulsifying agents, disintegrating agents. Application of polymers in medical purpose is increasing fast and used as a main tool to control the drug release rate from the formulations and drug delivery devices. 

Controlled drug delivery refers to the one which delivers the drug at a predetermined rate for locally or systemically for a specified period of time. The factors influencing the release of DDS include physicochemical properties of drug, physiological factors. Controlled DDS include the maintenance of drug levels within a desired range, the need for less administrations, increased patient compliance. Controlled release drug delivery employs drug encapsulating devices from which therapeutic agents may be released at controlled rates for longer periods of time, ranging from days to months.

Ocular administration of drug is primarily associated with the need to treat ophthalmic diseases. The major challenge met by todays pharmacologist and formulation scientist is ocular drug delivery. Scientists faced many challenges in Ocular drug delivery due to exceptional anatomy and physiology of eye. In ocular drug delivery there are two types of barriers which are static and dynamic barrier. The main problem in ocular drug delivery is rapid and extensive elimination of conventional eye drops from the eye. Therapeutic drug levels are not maintained for longer duration in target tissues. Moreover, various Nanoformulations have been introduced for ocular drug delivery.

Children differ from adults in aspects of pharmacotherapy, capabilities of drug administration, taste preferences. It is essential that pediatric medicines are formulated to best suit a child’s age, size, condition and treatment requirements. The pediatric formulation should be with flexible dosage and minimal excipients, palatable, safe and easy to administer. Mostly conventional drug delivery systems are not acceptable for pediatric patients as they differ in their developmental status and requirements from other population. Pediatric patients require different oral drug delivery. 

Implantable drug eluting devices also referred as Implantable drug delivery system. Implantable drug delivery systems are being developed to release drugs to the bloodstream continuously as well as free patients from being hospitalized to receive IV infusions or frequent injections. They can provide localized, site specific drug delivery which is especially important in applications such as cardiology and oncology where targeted delivery can improve the effectiveness of treatment and minimize side effects. 

The Vaccine Design and Delivery Group is an interdisciplinary and global group containing roughly 10 scientists of different foundations including drug specialists, researcher, organic chemists, physicists and biotechnologists. Since its revelation in 1796 by Edward Jenner, vaccines have been an essential part of therapeutics, opposing several infectious diseases with outstanding achievement. As of late, because of quick advances in proteomics, genomics, biotechnology and immunology and the overabundance of learning amassed in related fields, it is reasonable for vaccine development to advance at an exponential pace. Vaccines are stable, economical, require fewer doses and can be administered using needle free systems are universal significance.

Drug delivery devices are specialized tools for the delivery of a drug or therapeutic agent via a specific route of administration. Such devices are part of one or more medical treatments. With the business sectors for biosimilars and biologics surfacing, producers have the chance to innovate and design more complex delivery methods. As competition becomes increasingly tense in both the pharmaceutical and medical devices industries, companies have moved in the direction of creating drug delivery device as a chance to differentiate themselves and to diversify their portfolio.

The rising demand for innovative drugs is set to initiative research within the drug delivery market, promising new formulations and more choice for consumers. Rising demand for advancements in drug delivery has encouraged major pharmaceutical companies to continue reformulating drugs and improving upon medical favorites. Moreover, self-administration and residential care and increasing demand for biosimilars and http://pulsusconference.com/genetics-molecular-biology-meetings-workshopsgeneric medicine supply vital growth prospects for player operative within the market. On the other hand, risk of needle-stick injuries and side effects of medication might restraint the expansion of the market.

Pharmaceutical Analysis is an Analytical Method used to determination the quality and quantity of the pharmaceutical products. It also gives the information about the purity and safety of the products. Briefly it can be described as it identifies, determines, quantifies, purifies and separates the active compound from the mixture. The constituent may be a single compound or a mixture of compounds and may be in any of the dosage form. The substance used as pharmaceuticals are animals, plants, microorganisms, minerals and various synthetic products. Bioanalysis is a sub-discipline of analytical chemistry which cover biological molecules in unnatural locations or concentrations)  and the quantitative activity of xenobiotics (drugs and their metabolites and biotic (proteins, DNA, giant molecule medicine, macro and micro molecules, metabolites) in biological systems.