Ritu Singla
Project Manager II Labcorp Drug Development, Australia
Title: Title: Advanced Applications of Nano Drug Delivery Systems
Biography:
Abstract:
Statement of the Problem: Cancer is a world-wide problem. Better diagnostic technologies can improve cancer detection and outcomes from cancer treatments. Advanced diagnostic technologies such as nano delivery system serve as means of diagnostic tools or to deliver therapeutic agents (chemotherapeutic agents, biological agents, immunotherapeutic agents etc.) site-specific, and target-oriented delivery of precise medicines in a controlled manner. Methodology & Theoretical Orientation: The therapeutic progress of cell-based therapies was assessed by labelling chimeric antigen receptor (CAR) T-cells with novel radioactive labelled superparamagnetic iron oxide nanoparticle and tracked using clinical hybrid imaging modalities. Findings: The cell tracking platform in first-in-human studies provided real-time data on distribution, migration and localization of CAR-T cells. It further provided insight into physiology, efficacy and toxicities of cell based therapy. The dual imaging technology developed is simple, scalable, non-invasive and biocompatible and addressed the lack of effective imaging tools for cell-based therapies. It is not only suitable for early tumour detection but also for ongoing monitoring in oncology. In another study, a sustainable, reagent-less and one-pot ultrasonic methodology has been developed to transform natural biomaterials into micro/nanocrystals with distinct morphologies which then can be used to load anticancer drugs with high loading efficiency) for site specific and targeted delivery in controlled manner. The synthesized particles showed, high thermostability, antioxidant properties and a remarkable antiproliferative effect in human breast cancer cells. Conclusion & Significance: Nanomedicine has revolutionized the way we discover, image and administer drugs in biological systems. The first study validated and demonstrated the potential for cell tracking in immunotherapy. The second study emphasized on green chemistry to convert novel natural biomaterials into nano drug delivery system for precision medicine.