Shuhaib.B
Department of Pharmaceutics, Crescent College Of Pharmaceutical Sciences, Kannur, India
Biography:
Abstract:
The objective of the present investigation was formulate & characterize the microsponge of Mefenamic acid, these microsponges were prepared by quassi-emulsion method. Pre formulation studies by FTIR, revealed no interaction between pure drug and the different polymers used. The prepared microsponges were characterized for their production yield, drug content, mean particle size & entrapment efficiency, Effect of formulation variables was also studied. The microsponge containing 0.5 gm of poly vinyl alcohol, 0.6 gm of ethyl cellulose and 5ml ethanol was found to be good compared to the other formulations prepared. The best microsponges (M3, M6, and M9) were in cooperated into gel and emulgel. The topical gel and emulgel formulation were evaluated for their organoleptic characters, viscosity, spreadability, drug content and drug release studies. The results showed microsponge gel of mefenamic acid containing eudragit RS100 microsponge emulgel of mefenamic acid containing ethyl cellulose as best formulations, the in vitro drug release profile of mefenamic acid was found to better from the emulgel formulation compared to gel formulation.